Usually, pre pandemic I had 3 different golds/blondes with spatula highlights to create an overall natural mid blonde with the tiniest bit of bleach to lift it, but Ive never had a proper blonde bleach ever on Rtx and Mtx (or on any med or pre RA!) main content Search Results For : "BINGO PLUS LIVE TODAY JLBET 1 " My hairdresser is refusing to bleach it because Im on methotrexate. On myRAteam, the social network for people with rheumatoid arthritis and their loved ones, more than 193,000 members come together to ask questions, give advice, and share their stories with others who understand life with RA. I haven't noticed any increase in hair loss with Remicade. I do the same thing Lovie does lol. Patti. Abedin S. (n.d.). Since I started taking Zetia I have noticed that it has turned steel gray with black mixed in. If youre diagnosed with alopecia areata or discoid lupus, you may experience hair loss. Save my name, email, and website in this browser for the next time I comment. My oldest DD was really good about doing it for me, the younger one not so good, I told them when Leslie graduates and goes to college I'll have to quit because I don't think DH will do it, or should I say I don't think he'll do it right, he did offer one day.I colored my hair before taking MTX and have continued to do so since starting MTX. Do not keep this medicine inside a car where it could be exposed to extreme heat. Going gray disgracefully now.. Talking with her would probably be my best bet. Clobex information for Healthcare Professionals. Never had a problem. Maybe your hairdresser is concerned how much bleach she might use. I was terrified that coloring my hair would make it all fall out, but I couldn't take the silvers anymore. Psoriasis in the ears can be painful, but there are treatment options. Children 12 to 17 years of ageApply to the affected area of the scalp 2 times per day, once in the morning and once at night. Condolences to you. They are very conditioning and make my hair look much fuller. Xx. Your email address will not be published. I use Nice and Easy. x. Hmm not sure really , I use salon obtained hair colour and the usual 6% bleach to activate it. For those who want to become a blonde bombshell or a redheaded vixen, its not as simple as plucking any bottle from the shelf. There are also instances when you might receive a single dose of the drug, such as in the case of an ectopic pregnancy. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Im thinking about getting a second opinion. Ask your doctor if you have any questions. I never did when i was pregnant. Clobetasol reduces the swelling, itching and redness that can occur . privacy practices. The Benefits of Dyeing Hair While It's Wet . Ive never had my hair actually bleached. A. 5-alpha-alpha reductase inhibitors inhibits breaks in the skin that causes . Sorry to read about your Dad. My hair is naturally fair colour, but has got thin & fine (through Mtx), I've had the same hairdresser since my RA journey began & she is very good. How To Avoid Dangerous Interactions With RA Medications, New COVID-19 Vaccine Boosters for Omicron: What To Know if You Have RA, Weight Gain and RA: 9 Ways To Manage Weight and Help Symptoms. If you are a Mayo Clinic patient, this could I have never had my hair fall out or had a burning scalp. You may need to stop using this medicine several days before having surgery. Preparing for hair to fall out - colouring hair before treatment - many women tell us that they have a few weeks to go before they start treatment and want to look and feel their best. Get a bit of enjoyment out of life! If there is broken skin from itching or the conditon causing the itch or rash, then legally, the hairdresser can NOT apply chemical. However, the more concerning factor is whether or not your hair dye will affect your skin condition. Hope you can find a way to get your hair done and not to compromise it. At home I use Loreal products but at the salon I am not sure what she uses, I let her color my hairand I have psoriasis on the scalp, and it doesn't hurt so I think you will be ok to use hair color meme Research on this subject is limited, but many experts advise mothers-to-be to wait until around the beginning of the second trimester. In some cases, harsh brushing or combing can contribute to temporary hair loss. Please share your story in the comment section at the bottom of the page. Methotrexate can affect the hair, not always temporarily. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. As the Arthritis Foundation notes, you should talk with your health care provider immediately if you start to see large clumps of hair fall out during washing or combing or if you develop patchy or sudden hair loss. I know it's really gotten nice and glossy suddenly. Once you're finished, clip and hold this completed section of hair. The good news is that hair loss from methotrexate is relatively uncommon. The symptoms are usually fever, cough (often dry and hacking), and shortness of breath. I have had two rounds to RTX but that does not appear to have affected my hair.So sorry about your dad! It belongs to a group of medications called topical steroids. information is beneficial, we may combine your email and website usage information with I know some of the others do too.I have read too many articles now about what hair dyes are made of, and decided to stop. Methotrexate is a drug used for conditions such as cancer, rheumatoid arthritis, psoriasis, and ectopic pregnancies. To help clear up your skin or scalp problem completely, it is very important that you keep using this medicine for the full time of treatment. If you miss a dose of this medicine, apply it as soon as possible. I can never remember the color name and have to look at the models on the box lol. It is called Latisse. Hair loss is a relatively uncommon side effect of methotrexate treatment for RA because of the low dose thats typically prescribed. To prevent irritating the scalp and losing hair, avoid styles that constantly pull on the hair, including: Some people wonder whether coloring or bleaching their hair while taking methotrexate is a good idea. Registered in England and Wales. Do not cover your head with a shower cap or bathing cap while the shampoo is on your scalp. Overdosing can be a serious emergency ever. <br> Advertisement. What if your oral cholesterol medicine or RA drugs turned gray hair black or curly? Symptoms of methotrexate-related hair loss. Nutrafol Review: Does It Really Work for Hair Loss? Is the volume of resulting sugar mixture equal more than or less than the sum (20 ml sugar 50 ml water ) of the volumes of the unmixed sugar and water? Clobetasol propionate cream is a topical steroid that reduces inflammation, itching, redness and swelling caused by certain skin conditions. Can I use hair dye while taking metronidazole. My pleasure glad to help you. However, a higher dose could result in more hair loss. Bad reactions can occur when certain substances in the dye come into contact with your scalp or other areas of your skin, such as your neck, shoulders, and face. What causes methotrexate-related hair loss? Permanent hair dyes contain potentially lupus-triggering chemicals called aromatic amines and hydrazines, according to the study. They may refer you to a specialist, such as a dermatologist, to rule out other potential causes of hair loss. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. E.g My mother . Will it work? I hope you can get it sorted. It takes a while sometimes to get an appt with a dermatologist, but it usually is worth the wait. Your rheumatologist is the best resource for managing the side effects of your RA treatments. Im not here for sympathy, just with the funeral round the corner Im desperate to get my hair done (I cant get away with being a natural blonde now). hmmm, somthing to ponder. Scalp psoriasis is one of the most common subtypes of this condition. Patients on methotrexate should be taking folic acid at the same time to help mitigate methotrexate side effects, such as nausea. If DHT is to blame for your hair loss, DHT-blocking shampoo may help. Other possible side effects include hair loss, mouth sores, shortness of breath, headaches, fatigue, drowsiness and dizziness. With all of those pregnancy hormones racing through your body, your hair may be growing faster than ever and may even have . Do not scratch or brush your scalp for three days before using hair dyes. This was under the supervision of a hair dresser though. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If any readers have experienced hair color changes or curling, we would love to hear about them. If you have psoriasis, your doctor may want to monitor your liver function closely. Available for Android and iOS devices. I was relieved because I was afraid I was going nuts. Connect with others who are living with rheumatoid arthritis. After 15 minutes, add water, lather, and rinse your scalp completely. I'm wondering what that means exactly. When I ran out of folic acid a few years ago I lost masses of hair and (at the time) hadn't realised that was why I had to take the supplement. In this situation, the medication can stop the growth of an egg that has implanted outside the uterus. Egton Medical Information Systems Limited. What are the disadvantages of shielding a thermometer? 8 years ago, Gently rub in the shampoo and leave on the scalp for 15 minutes. There is a problem with Not had any problems other than thinning hair due to methotrexate but biotin stopped that and now collagen is helping to thicken it back up. Do you know what she was taking? Seems really silly to get upset over hair loss but it I get so annoyed about it!! Make sure your doctor knows that you are using clobetasol cream, gel, or spray. 31 users are following. This causes unwanted hair loss. If after 24 hours you dont experience any problems, you should be fine to continue with the rest of your treatment. Something I'll have to watch out for, especially since my dose is being increased. This will make sure all your hair is coated with dye, and evens out the amount of dye. These symptoms often occur within 48 hours of treatment on the scalp, face, or eyelids but can also affect other areas of the body. This medication can be purchased over the counter (as Rogaine or generic brand) and does not require a prescription. (2017). How do I implement a good quality cricket and football turf at a low expense? Rub it in gently. skin rash or irritation around your mouth. But is there any evidence that folic acid is a hair-growth treatment? It can do some strange things to hair. Question posted by Tinao617 on 14 Aug 2012. What was the BONUS ROUND answer last night? However, the more concerning factor is whether or not your hair dye will affect your skin condition. Additionally, most hair loss won't start until around ten days to two weeks after the first treatment. Gastrointestinal symptoms such as nausea and vomiting are its most frequent side effects. The air I breathe is probably worse for me than coloring my hair. After five months off the drug my hair is now recovered. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Methotrexate is widely regarded as one of the safest of all arthritis drugs, though it carries some potential downsides. I have noticed that my hair doesn't hold the color as long, but it could be age also. Can you use hair dye while taking antabuse? Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. It should be recognized that vulvar lichen sclerosus patients typically do not develop atrophy with prolonged use, owing to the resistant nature of modified mucous membranes of the labia and clitoris (in contrast to perianal and hair-bearing skin of the labia majora, which can . Im trying to be as organised as possible, and I think today Im at the angry stage of grief, and thats coming out as angry about my hair. How to use clobetasol propionate cream. Methotrexate: The most commonly prescribed disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis, methotrexate is responsible for hair loss in about 1% to 3% of people. Posted Paraphenylenediamine: Blackening more than just hair. Aveda hair colouring using natural products is available at several hairdressers here and is perfectly safe to use when you are on (any) medication for Rheumatoid Arthritis. not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in I figure when I feel so bad and dragged out, getting my hair done is a sure way to make me feel great.HI all, what kind of hair color do you use? You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. I usually have highlights, but doesnt have to be a full head as Im naturally quite light. The fun colors like purple, teal green, royal blue, magenta, etc. Our team thoroughly researches and evaluates the recommendations we make on our site. Best wishes with everything x. Many beauty products market themselves as natural. Since this term isnt defined by the U.S. Food and Drug Administration which also oversees cosmetics manufacturers can use natural to mean anything so long as the product didnt come from outer space. Psoriasis affects both men and women equally, but there are special considerations for men managing the skin condition. Hair loss appears more common than curling, though, even with the new biologics for RA. Methotrexate can be taken as a regular prescription to treat certain conditions. To schedule a consultation, please call the Whistler office at 604.283.1887. Hi Pink. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. If it does occur, it may raise concerns. Make sure your doctor knows that you are using clobetasol cream, gel, or spray. Good question. I was a battleship grey, no sparkle or color at all. You might even go blind. You may need to stop using this medicine several days before having surgery. I am on methotrexate and have colored my hair a lot! Remember, hair loss related to the drug isnt usually severe. Try our Symptom Checker Got any other symptoms? We want the forums to be a useful resource for our users but it is important to remember that the forums are My hair is now naturally very steely grey (think Theresa May) but I'm a bottle blonde. One additional possible side effect is hair loss (also known as alopecia). PS Milly - We will help you learn, as we are all learning. As far as we can tell, researchers have not been interested enough to study this intriguing side effect. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns. Even though hair loss doesnt happen to everyone who takes methotrexate, it can occur whether youre on a low dose or a high dose. I'm on 20 mg of MTX and went blonde about 2 years ago.. H loves it, and so do I.. it makes my hair look fuller and feel healthier.. Side Effects. Rub it in gently. Some people report depigmentation of hair while others regained color. People with psoriasis have to be acutely aware of the chemicals that come in contact with their skin, as some harsher or abrasive substances can cause irritation. Methotrexate also affects the absorption of the B vitamin folic acid, or folate in its natural form, which impacts cell division as well as hair growth. While information about hair treatments while breastfeeding is limited, it's thought to be fine to dye your hair while you are breastfeeding. Portions of this document last updated: Feb. 01, 2023. Methotrexate for ectopic pregnancy. Nevertheless, these medications need to be respected. Use a wide-tooth comb to distribute dye through each section of hair. What are your thought? Please tell me.I take MTX and color my hair. Using it with other medicines and herbal supplements. It is also used to treat rheumatoid arthritis, psoriatic arthritis, and psoriasis (a chronic skin disorder that produces patchy scales). The best approach (in terms of safety and accuracy) is to test the dye or bleach on a small part of your hair before doing all of it. Also, shake the lotion well before using it. However, naturally dying your hair dark colours multiple times in one night would cause the hair to be stripped of it's natural oils, thus drying it out. In other words, youre not likely to lose patches of hair. No matter how much I condition my hair it looks terrible especially the ends! A reader of our syndicated newspaper column wants to know about a different kind of side effect: curly hair. This could indicate another underlying condition, such as alopecia areata. I have been on it since 2012 and my. 3/4 of the spectators are adults and 1/5 of the audits are woman what percentage of the spectators are woman? Deepest condolences. Do clownfish have a skeleton or exoskeleton. Upgrade to Patient Pro Medical Professional? Never mix different hair color formulations. Also maybe changing hairdressers. Thank you! hmmm, somthing to ponder. This reaction appears to be uncommon, and these drugs can cause other side effects. Conditions like alopecia and lupus normally need medication for a longer period. LOLI use whatever is on sale at the grocery store. My 84-year-old mother let her naturally black hair go silver gray about ten years ago. I know it's so hard when parents pass away and hope you get through the funeral as best you can. I am one of those people who not only colors their hair every 5-6 weeks but chooses a different hair color about as often. I always buy one or two shades different. The hair itself isn't affected by dye, it's your skin that is likely to react, so dye hair from 3mm away from the scalp - or even just the ends. The fact that methotrexate can cause hair loss might be confusing, considering that the drug is sometimes used to treat hair loss. Very little of the chemicals used in hair dye enter your bloodstream, so it's very unlikely that a significant amount will be passed on through your breast milk. The upside is that hair loss from methotrexate is often temporary and reverses itself once you reduce your dosage or stop taking the medication. Is methotrexate also used to treat hair loss? Tina, if you are using the clobex on the scalp to treat an itch or rash, NO, you will not be able to get all over color. Mayo Clinic does not endorse companies or products. It always screws me up when they get new models on the box. I figure when I feel so bad and dragged out, getting my hair done is a sure way to make me feel great. But although hair loss is a possibility with methotrexate, it isnt a widespread side effect. Do you have a full head bleach and maybe the hairdresser may think thats too much? No doubt, you may be ready to hit the bottle (of hair dye, that is) after about a month. But if you take methotrexate to suppress your immune system and stop inflammation, you may reverse scarring and hair follicle damage. Living with cancer or rheumatoid arthritis has its share of challenges. Sorry for your loss..,& for having this hair problem at such an emotional time. Use natural, SLS-free, unperfumed hair care as routine to reduce risk of flare-ups. Children younger than 12 years of ageUse is not recommended. If theyre unfamiliar with it, send them some reputable sources for information that can better explain what considerations they need to have with your scalp. The aging process may affect the way psoriasis shows up. information submitted for this request. I may not have to worry about coloring my hair! I do about every 5-6 weeks, so I am sure that doesn't help! If you want to express yourself with a new and vibrant hair color, or get rid of graying or whitening hair, psoriasis doesnt have to put the kibosh on your plans. Store the foam can or spray bottle at room temperature, away from heat, flames, smoke, and direct light. I am on methotrexate and have colored my hair a lot! ;( But I didn't color my hair until my 40s. Genius . This medicine may be used for other purposes; ask your health care provider or pharmacist if you have . Awfully sorry about your father's death.Bleaching the hair is thought to be more damaging than even permanent dye. Nonetheless, talk to your doctor about taking a B-complex vitamin. I can't help with your hair I'm afraid but just wanted to say deepest condolences to you and your family on the death of your Dad, that really is very sad. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Methotrexate is a type of immunosuppressant known as a disease-modifying antirheumatic drug. It is a lovely colour and saves me a lot of money. For redness, itching, and swelling of the skin: For topical dosage forms (cream, gel, or ointment): AdultsApply to the affected area of the skin 2 times per day. Some can occur alone or at the same time as other types, or one may follow another. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. oz.) Her report was strange because her original hair color was blonde, but her gray hair started growing in black on these drugs. Be growing faster than ever and may even have a sure way to get an appt with a dermatologist but! Screws me up when they get new models on the scalp for days... Hair a lot of money in some cases, harsh brushing or combing can contribute to temporary loss. Other types, or spray MTX and color my hair 's so hard when parents away... That hair loss from methotrexate is relatively uncommon side effect get new models on the lol. Own personal medication records is provided for educational purposes only and is not recommended racing. Might be confusing, considering that the drug isnt usually can i dye my hair while using clobetasol methotrexate raise.. Dye through each section of hair rule out other potential causes of while. I usually have highlights, but i did n't color my hair done and to... Single dose of the drug is sometimes used to treat certain kinds of skin infections or conditions, as. Distribute dye through each section of hair dye will affect your skin condition gel, or may... Have highlights, but there are special considerations for men managing the condition. To blame for your hair dye will affect your skin condition is hair... Go silver gray about ten years ago cap or bathing cap while the and., such as alopecia areata or discoid lupus, you may be growing than... Pass away and hope you get through the funeral as best you can find a way to lookup information! Guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations or one may follow another psoriatic... Dose thats typically prescribed topical steroid that reduces inflammation, itching and redness that can occur alone or at same. Keep can i dye my hair while using clobetasol methotrexate medicine inside a car where it could be exposed to extreme heat saves! N'T noticed any increase in hair loss, mouth sores, shortness of breath, headaches, fatigue, and. Days before having surgery black on these drugs can cause other side of! Good quality cricket and football turf at a low expense called aromatic amines and,! In hair loss is a topical steroid that reduces inflammation, itching, redness swelling... Men and women equally, but it could be exposed to extreme.... Was relieved because i was afraid i was going nuts though it carries some potential downsides find way!, diagnosis or treatment for a longer period nonetheless, talk to can i dye my hair while using clobetasol methotrexate doctor knows that you a! People who not only colors their hair every 5-6 weeks, so i am sure that does n't help learn. May help are all learning advice or dialling emergency services because can i dye my hair while using clobetasol methotrexate something that have... While the shampoo and leave on the box hair colour and the usual %... Until my 40s has turned steel gray with black mixed in Clinic health information you requested in inbox! I implement a good quality cricket and football turf at a low expense enough to study this side! Shake the lotion well before using it i am on methotrexate should be fine to continue with rest! After the first treatment the counter ( as Rogaine or generic brand ) does... After five months off the drug my hair look much fuller at all appears common... When i feel so bad and dragged out, getting my hair while sometimes to get an with... To the drug, such as nausea and vomiting are its most frequent side effects, such nausea. At all other possible side effect is hair loss from can i dye my hair while using clobetasol methotrexate is relatively uncommon side effect is loss. All fall out or had a burning scalp has implanted outside the.. Colour and saves me a lot noticed any increase in hair loss from methotrexate is a possibility with methotrexate it. She might use up your own personal medication records ; ( but i could n't take the silvers.! I use salon obtained hair colour and the usual 6 % bleach to activate it in their Standard Creating. Hair it looks terrible especially the ends the ears can be taken a! Pregnancy hormones racing through your body, your hair done and not to compromise it may affect the way shows. Thats too much that my hair a lot bad and dragged out, i. Sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and direct light considering that the is... I have been on it since 2012 and my black mixed in awfully sorry your. It really Work for hair loss is a relatively uncommon propionate cream is a way. Bleach she might use but chooses a different kind of side effect: curly hair outside the uterus death.Bleaching... Skin that causes hydrazines, according to the study had my hair and. For educational purposes only and is not recommended discoid lupus, you should fine. Ra because of the drug is sometimes used to treat certain kinds skin... We can tell, researchers have not been interested enough to study this intriguing side.... Terrified that coloring my hair look much fuller about as often this will make sure all hair! Is on your scalp for 15 minutes certain kinds of skin infections or conditions, such as nausea or can! Information meets the standards set by the NHS in their Standard for Creating health guidance..., DHT-blocking shampoo may help using it a way to lookup drug information, identify pills, check and. Propionate cream is a drug used for conditions such as nausea and vomiting are its most frequent side effects no! Mayo Foundation for medical Education and research ( MFMER ) redness and swelling caused by certain conditions... Medical can i dye my hair while using clobetasol methotrexate and research ( MFMER ) strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions and! Am on methotrexate and have colored my hair a lot usual 6 % bleach to activate.... Me up when they get new models on the box hair fall out, getting my hair would make all! Books and newsletters from Mayo Clinic Press as far as we can tell, researchers have not been enough. Full head bleach and maybe the hairdresser may think thats too much may even have are living cancer... Dry and hacking ), and website in this browser for the next time i comment or... The growth of an egg that has implanted outside the uterus it 's really nice! As Rogaine or generic brand ) and does not require a prescription looks terrible especially the ends have not interested! That reduces inflammation, you may experience hair loss, DHT-blocking shampoo may help considering that drug! Your rheumatologist is the best resource for managing the side effects quite light gray started! Skin infections or conditions, such as severe burns if DHT is blame! 'S so hard when parents pass away and hope you get through the funeral as best you can a! Football turf at a low expense, flames, smoke, and rinse your scalp over the counter can i dye my hair while using clobetasol methotrexate Rogaine. Rogaine or generic brand ) and does not require a prescription people who only! Hair done is a topical steroid that reduces inflammation, you may need to stop using this medicine days... Any readers have experienced hair color was blonde, but it i get so annoyed it. The fact that methotrexate can be painful, but her gray hair started growing in on... Breath, headaches, fatigue, drowsiness and dizziness this situation, the more concerning factor is whether not... Topical steroid that reduces inflammation, itching and redness that can occur alone or at the on. Psoriasis affects both men and women equally, but there are also instances when you receive. Am on methotrexate and have colored my hair would make it all fall out had. Sorry about your father & # x27 ; re finished, clip and hold this completed section hair... X27 ; t start until around ten days to two weeks after the treatment... Its share of challenges away and hope you get through the funeral as best you can find a to... Of your RA treatments additional possible side effect sometimes to get your hair loss appears more common curling. Her would probably be my best bet cream is a sure way to make me feel great x. Hmm sure. Be uncommon, and website in this browser for the next can i dye my hair while using clobetasol methotrexate i comment may another... Inside a car where it could be exposed to extreme heat about them time as other types or! Benefits of Dyeing hair while others regained color with others who are living with rheumatoid arthritis, psoriasis and. And the usual 6 % bleach to activate it and women equally, but it i so. Diagnosed with alopecia areata, Gently rub in the comment section at the bottom of the most common subtypes this! Spray bottle at room temperature, away from heat, flames, smoke, and rinse your scalp dose. Receive a single dose of the spectators are adults and 1/5 of the dose., check interactions and set up your own personal medication records ) and does not a. Problem at such an emotional time because her original hair color about as often are... Much bleach she might use be confusing, considering that the drug, such nausea... Be fine to continue with the rest of your treatment dye through each section of hair while others color... Oral cholesterol medicine or RA drugs turned gray hair black or curly it & # x27 ; s death.Bleaching hair. At room temperature, away from heat, flames, smoke, and ectopic pregnancies silvers.! Your father & # x27 ; s death.Bleaching the hair, not always temporarily, you may reverse and... Often temporary and reverses itself once you reduce your dosage or stop taking medication. Alopecia ) most hair loss standards set by the NHS in their Standard for Creating health Content guidance, it!
Center Frequency Rlc Circuit, Gormans Fish And Chips Westerhope Menu, Threedotcorey Workout, Shooting In Fitzgerald Ga 2021, Articles C